在注射量相同的情况下，左旋布比卡因用于小儿腹股沟疝修补术中骶管内术中镇痛的最佳浓度。

The optimum concentration of levobupivacaine for intra-operative caudal analgesia in children undergoing inguinal hernia repair at equal volumes of injectate.

作者信息

Yao Y-S, Qian B, Chen B-Z, Wang R, Tan L

机构信息

Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

出版信息

Anaesthesia. 2009 Jan;64(1):23-6. doi: 10.1111/j.1365-2044.2008.05688.x.

DOI:10.1111/j.1365-2044.2008.05688.x

PMID:19087002

Abstract

Probit analysis was used to predict the median effective concentration (EC(50)) and the 95% effective concentration (EC(95)) values of levobupivacaine for caudal analgesia in children at equal volumes of injectate. Sixty children scheduled for inguinal herniorrhaphy were recruited. Anaesthesia was induced with sevofurane and nitrous oxide. Then caudal block (total volume of local anaesthetic 1 ml.kg(-1)) was performed. Patients randomly received one of six concentrations (0.08%, 0.10%, 0.12%, 0.14%, 0.16% or 0.18%) of levobupivacaine. Thereafter, inhalational anaesthetics were discontinued and intravenous midazolam 0.1 mg.kg(-1) was administered to maintain sedation. The effective caudal analgesia was defined as an absence of gross movements and a haemodynamic (heart rate or blood pressure) reaction < 20% compared with baseline in response to surgical incision. Our data indicated that the EC(50) and EC(95) values of levobupivacaine for caudal analgesia were 0.109% (95% confidence intervals 0.098-0.120%) and 0.151% (95% confidence intervals 0.135-0.193%) when using the same volume (1 ml.kg(-1)), respectively.

摘要

采用概率单位分析来预测等容量注射时左布比卡因用于小儿骶管镇痛的半数有效浓度（EC(50)）和95%有效浓度（EC(95)）值。招募了60例计划行腹股沟疝修补术的儿童。用七氟烷和氧化亚氮诱导麻醉。然后实施骶管阻滞（局部麻醉药总量1 ml·kg⁻¹）。患者随机接受六种浓度（0.08%、0.10%、0.12%、0.14%、0.16%或0.18%）之一的左布比卡因。此后，停用吸入麻醉药并给予静脉注射咪达唑仑0.1 mg·kg⁻¹以维持镇静。有效的骶管镇痛定义为对手术切口无明显动作且血流动力学（心率或血压）反应较基线变化<20%。我们的数据表明，使用相同容量（1 ml·kg⁻¹）时，左布比卡因用于骶管镇痛的EC(50)和EC(95)值分别为0.109%（95%置信区间0.098 - 0.120%）和0.151%（95%置信区间0.135 - 0.193%）。