Servizio di Neurofisiopatologia, Policlinico Tor Vergata, Centro di Medicina del Sonno, University of Rome 'Tor Vergata', Rome, Italy.
Eur J Neurol. 2009 Jan;16(1):70-5. doi: 10.1111/j.1468-1331.2008.02347.x.
To evaluate the effects of pregabalin (PGB) adjunctive therapy on sleepwake cycle and daytime somnolence in adult patients affected by partial epilepsy.
Twelve patients affected by partial epilepsy underwent a 24-h ambulatory polysomnography and a subjective evaluation of daytime somnolence by means of the Epworth Sleepiness Scale (ESS), before and after 3 months treatment with PGB.
Pregabalin therapy reduced seizures by >50% in 8 out of 12 patients. It induced a significant increase of REM sleep and a decrease of stage 2 NREM sleep (S2). A significant increase of the ESS score was observed without reaching the pathological cut-off value (mean ESS score <10). No statistical correlation between REM sleep and seizure frequency was observed.
Pregabalin seems to be effective and safe in partial epilepsy. The increase of REM sleep may be indicative of an improvement of nocturnal sleep quality considering the involvement of REM sleep in learning and memory processes. REM sleep enhancement may be the result of both a direct effect of PGB on sleep generators and an indirect effect due to its clinical efficacy. The increase of ESS score within normal range suggests that daytime somnolence is a minor adverse effect of PGB.
评估普瑞巴林（PGB）辅助治疗对部分癫痫成人患者睡眠-觉醒周期和日间嗜睡的影响。
12 例部分癫痫患者在接受普瑞巴林治疗 3 个月前后，分别进行了 24 小时动态多导睡眠图和日间嗜睡的 Epworth 嗜睡量表（ESS）主观评估。
8 例患者中的 12 例经 PGB 治疗后，癫痫发作减少了 >50%。它诱导 REM 睡眠显著增加，NREM 睡眠第 2 期（S2）减少。ESS 评分显著增加，但未达到病理截止值（平均 ESS 评分<10）。未观察到 REM 睡眠与癫痫发作频率之间存在统计学相关性。
普瑞巴林对部分癫痫似乎是有效且安全的。考虑到 REM 睡眠在学习和记忆过程中的参与，REM 睡眠的增加可能表明夜间睡眠质量得到改善。REM 睡眠增强可能是 PGB 对睡眠产生器的直接作用和由于其临床疗效的间接作用的结果。ESS 评分在正常范围内增加表明日间嗜睡是 PGB 的一个较小的不良反应。
