Department of Neurology, West China Hospital of Sichuan University, 37th Guoxuexiang Road, Chengdu, Sichuan 610041, China.
J Clin Neurosci. 2012 Jul;19(7):956-60. doi: 10.1016/j.jocn.2011.09.032. Epub 2012 May 16.
This study investigated the effect of the novel antiepileptic drug levetiracetam (LEV) on sleep in eleven patients with partial epilepsy. At baseline and one week after therapy with LEV (1000 mg/day), patients underwent polysomnography (PSG) and the Multiple Sleep Latency Test (MSLT). Patients also rated their own degree of sleep disturbance and daytime sleepiness with the Athens Insomnia Scale (AIS) and the Epworth Sleepiness Scale (ESS). A group of 10 age- and gender-matched control participants were also included in the study. Patients had decreased total sleep time and increased daytime sleepiness compared to baseline, as evaluated by AIS subscales. Furthermore, LEV therapy significantly decreased the rapid eye movement sleep time and percentage as measured by PSG. Patients reported a significant increase in ESS score but did not exhibit changes in MSLT performance after LEV treatment. The study demonstrated that short-course LEV treatment can affect subjective sleep time and objective sleep architecture. Furthermore, LEV treatment affected subjective daytime sleepiness but did not influence objective mean daytime sleep latencies in patients with partial epilepsy.
本研究旨在探讨新型抗癫痫药物左乙拉西坦（LEV）对 11 例部分性癫痫患者睡眠的影响。在基线和 LEV 治疗一周后（1000mg/天），患者接受了多导睡眠图（PSG）和多次睡眠潜伏期试验（MSLT）。患者还使用雅典失眠量表（AIS）和 Epworth 嗜睡量表（ESS）评估自己的睡眠障碍和白天嗜睡程度。研究还纳入了一组 10 名年龄和性别匹配的对照组参与者。与基线相比，患者的 AIS 子量表评估显示总睡眠时间减少，白天嗜睡增加。此外，PSG 测量显示，LEV 治疗显著减少了快速眼动睡眠时间和百分比。患者报告 ESS 评分显著增加，但 LEV 治疗后 MSLT 表现无变化。该研究表明，短期 LEV 治疗可能会影响主观睡眠时间和客观睡眠结构。此外，LEV 治疗影响了部分性癫痫患者的主观白天嗜睡程度，但不影响客观平均白天睡眠时间。
