经腹与经宫颈绒毛取样在产前诊断临床应用中的比较

[Comparison between transabdominal and transcervical chorionic villus sampling in clinical application for prenatal diagnosis].

作者信息

Luo Yan-Min, Fang Qun, Yang Yong-Zhong, Chen Jun-Hong, Chen Min-Ling, Chen Yong-Zhen

机构信息

Fetal Medicine Center, Department of Obstetrics and Gynecology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China.

出版信息

Zhonghua Fu Chan Ke Za Zhi. 2008 Nov;43(11):814-7.

PMID:19087562

Abstract

OBJECTIVE

To compare transabdominal and transcervical chorionic villus sampling (TC-CVS) in application for prenatal diagnosis, and to summarize the experience of transabdominal chorionic villus sampling (TA-CVS).

METHODS

One hundred and nine TA-CVS between April 2005 and November 2007 and 69 TC-CVS between August 1999 and March 2005 were retrospectively analyzed.

RESULTS

(1) The mean gestational age was (12.4 +/- 1.9) weeks at TA-CVS and (8.8 +/- 1.2) weeks at TC-CVS (P < 0.01). (2) Compared with TC-CVS, punctures were fewer (1.4 +/- 0.5) and (1.1 +/- 0.4) and specimen amount was more (9 +/- 5) mg and (17 +/- 5) mg in TA-CVS, and the success rate of one puncture (62.3% vs 87.2%) was higher in TA-CVS. (3) Among the cases followed up, the incidence of vaginal bleeding (TA-CVS: 2 cases, 2.0%; TC-CVS: 2 cases, 6.1%) and spontaneous abortion (TA-CVS: 4 cases, 4.0%; TC-CVS: 1 cases, 3.0%) were not significantly different between the two groups (P > 0.05).

CONCLUSION

TA-CVS appears to be a good method for early prenatal diagnosis with a wide range of indications, high success rate and sufficient specimen.

摘要

目的

比较经腹绒毛取样术（TA-CVS）和经宫颈绒毛取样术（TC-CVS）在产前诊断中的应用，并总结经腹绒毛取样术的经验。

方法

回顾性分析2005年4月至2007年11月间109例TA-CVS及1999年8月至2005年3月间69例TC-CVS。

结果

（1）TA-CVS时平均孕周为（12.4±1.9）周，TC-CVS时为（8.8±1.2）周（P<0.01）。（2）与TC-CVS相比，TA-CVS穿刺次数较少（分别为1.4±0.5次和1.1±0.4次），标本量较多（分别为9±5mg和17±5mg），且TA-CVS一次穿刺成功率较高（62.3%对87.2%）。（3）在随访病例中，两组间阴道出血发生率（TA-CVS：2例，2.0%；TC-CVS：2例，6.1%）和自然流产发生率（TA-CVS：4例，4.0%；TC-CVS：1例，3.0%）差异无统计学意义（P>0.05）。