末端横向肢体缺陷与早期绒毛取样：4300例完整随访病例的评估

Terminal transverse limb defects and early chorionic villus sampling: evaluation of 4,300 cases with completed follow-up.

作者信息

Jahoda M G, Brandenburg H, Cohen-Overbeek T, Los F J, Sachs E S, Wladimiroff J W

机构信息

Department of Obstetrics and Gynaecology, Academic Hospital Rotterdam-Dijkzigt, The Netherlands.

出版信息

Am J Med Genet. 1993 Jun 15;46(5):483-5. doi: 10.1002/ajmg.1320460503.

DOI:10.1002/ajmg.1320460503

PMID:8322804

Abstract

Data from 4,300 consecutive cases following prenatal diagnosis by transcervical (TC) CVS (n = 1,570) and transabdominal (TA) CVS (n = 2,370) were evaluated. In the follow-up study only infants examined by a physician were included. Gestational age varied between 8.5 and 11.6 weeks (mean 10.3 weeks) for TC-CVS and between 9.3 and 20 weeks (mean 12.3 weeks) for TA-CVS 98% of TC-CVS was performed at 9-10 weeks, 80.7% of TA-CVS procedures were carried out at 12-15 weeks. Selective termination took place in 97 cases of TC-CVS (6.1%) and in 72 cases of TA-CVS (2.6%). Another 8 women had a termination for psychosocial reasons, resulting in 4,123 (1,469 TC, 2,654 TA) continuing pregnancies. The overall fetal loss rate < 28 weeks was 5.4% (n = 80) for TC-CVS and 2.6% (n = 70) for TA-CVS. The overall incidence of congenital abnormalities after birth was 0.9%. Two terminal transversal limb defects were detected in the TC-CVS group (0.14%) against one (0.04%) in the TA-CVS group.

摘要

对4300例经宫颈（TC）绒毛取样术（n = 1570）和经腹（TA）绒毛取样术（n = 2370）进行产前诊断后的连续病例数据进行了评估。在后续研究中，仅纳入了由医生检查的婴儿。TC - CVS组的孕周在8.5至11.6周之间（平均10.3周），TA - CVS组的孕周在9.3至20周之间（平均12.3周）。98%的TC - CVS在9 - 10周进行，80.7%的TA - CVS手术在12 - 15周进行。TC - CVS组有97例（6.1%）进行了选择性终止妊娠，TA - CVS组有72例（2.6%）。另外8名女性因社会心理原因终止妊娠，导致4123例（1469例TC，2654例TA）继续妊娠。TC - CVS组<28周的总体胎儿丢失率为5.4%（n = 80），TA - CVS组为2.6%（n = 70）。出生后先天性异常的总体发生率为0.9%。TC - CVS组检测到2例末端横向肢体缺陷（0.14%），TA - CVS组为1例（0.04%）。