Wang Zhi, Zhang Ben, Jiang Lu, Zeng Xin, Chen Yu, Feng Xiaodong, Guo Yu, Chen Qianming
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, PR China.
Eur J Cancer. 2009 Feb;45(3):490-6. doi: 10.1016/j.ejca.2008.11.012. Epub 2008 Dec 16.
The aim of this study was to evaluate the significance of RACK1 in predicting outcome for patients with oral squamous cell carcinoma (OSCC) compared with Ki67.
The expression of both RACK1 and Ki67 in 130 patients with OSCC was illustrated by using immunohistochemistry assay. Multiple logistic regression and Pearson's correlation coefficient were used. Recurrence versus non-recurrence of the malignant lesions was considered as the surrogate for clinical outcome of patients.
Multivariable logistic regression showed that the elevated RACK1 immunostaining was a factor having great influence on OSCC prognosis. RACK1 staining was strongly related to that of Ki67. The area under the receiver operating characteristic curve for both biomarkers in predicting recurrence was 0.72 and 0.70 respectively, indicating an excellent discrimination for RACK1 as well as for Ki67.
These data indicate that increased RACK1 expression is an important outcome predictor for OSCC compared with Ki67.
本研究旨在评估与Ki67相比，RACK1在预测口腔鳞状细胞癌（OSCC）患者预后方面的意义。
采用免疫组织化学分析法检测130例OSCC患者中RACK1和Ki67的表达。使用多因素逻辑回归和Pearson相关系数。将恶性病变的复发与未复发作为患者临床结局的替代指标。
多变量逻辑回归显示，RACK1免疫染色升高是对OSCC预后有重大影响的一个因素。RACK1染色与Ki67染色密切相关。两种生物标志物预测复发的受试者工作特征曲线下面积分别为0.72和0.70，表明RACK1和Ki67均具有良好的辨别能力。
这些数据表明，与Ki67相比，RACK1表达增加是OSCC的一个重要预后预测指标。
