先兆子痫女性的血浆会刺激中性粒细胞的跨内皮迁移。
Plasma from preeclamptic women stimulates transendothelial migration of neutrophils.
作者信息
Walsh Scott W
机构信息
Department of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA.
出版信息
Reprod Sci. 2009 Mar;16(3):320-5. doi: 10.1177/1933719108327594. Epub 2008 Dec 15.
Abstract
UNLABELLED
Neutrophils infiltrate systemic vasculature of women with preeclampsia, so we tested the hypothesis that factors in plasma of preeclamptic women activate endothelial cells to produce IL-8 resulting in transendothelial migration of neutrophils. Neutrophil migration was studied using the Transwell system. An endothelial cell line was grown to confluence on the inserts and treated with 10% plasma from normal nonpregnant (NNP), normal pregnant (NP) and preeclamptic (PE) women or with an oxidizing solution containing linoleic acid (OxLA). Compared to medium control, NNP plasma or NP plasma, PE plasma significantly stimulated IL-8 and neutrophil migration which was inhibited by vitamins E and C or IL-8 neutralizing antibody. Compared to medium control or LA, OxLA stimulated IL-8 and neutrophil migration which was inhibited by vitamins E and C or IL-8 antibody.
CONCLUSION
Factors present in plasma of preeclamptic women stimulate transendothelial migration of neutrophils which is due to induction of oxidative stress and production of IL-8.
摘要
未标记
中性粒细胞浸润子痫前期女性的全身血管系统，因此我们检验了以下假设：子痫前期女性血浆中的因子激活内皮细胞产生白细胞介素-8（IL-8），从而导致中性粒细胞的跨内皮迁移。使用Transwell系统研究中性粒细胞迁移。将一种内皮细胞系在小室上培养至汇合，并用来自正常未孕（NNP）、正常妊娠（NP）和子痫前期（PE）女性的10%血浆或含有亚油酸的氧化溶液（OxLA）处理。与培养基对照、NNP血浆或NP血浆相比，PE血浆显著刺激IL-8和中性粒细胞迁移，而维生素E和C或IL-8中和抗体可抑制这种迁移。与培养基对照或亚油酸（LA）相比，OxLA刺激IL-8和中性粒细胞迁移，而维生素E和C或IL-8抗体可抑制这种迁移。
结论
子痫前期女性血浆中的因子刺激中性粒细胞的跨内皮迁移，这是由于氧化应激的诱导和IL-8的产生。
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