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白血病抑制因子可维持在TM4饲养层上培养的小鼠原始生殖细胞的存活。

Leukemia inhibitory factor sustains the survival of mouse primordial germ cells cultured on TM4 feeder layers.

作者信息

De Felici M, Dolci S

机构信息

Department of Public Health, II University of Rome, Italy.

出版信息

Dev Biol. 1991 Sep;147(1):281-4. doi: 10.1016/s0012-1606(05)80025-9.

DOI:10.1016/s0012-1606(05)80025-9
PMID:1908801
Abstract

Various growth factors and cytokines were tested for their effects on survival and proliferation of mouse primordial germ cells (PGCs) cultured on TM4 cell feeder layers. Leukemia inhibitory factor was able to sustain the survival of PGCs from 10.5 dpc embryos for at least 3 days and to slow down degeneration of PGCs from 11.5 dpc embryos cultured on TM4 feeder layers.

摘要

测试了多种生长因子和细胞因子对在TM4细胞饲养层上培养的小鼠原始生殖细胞（PGC）存活和增殖的影响。白血病抑制因子能够维持来自10.5天妊娠龄胚胎的PGC存活至少3天，并减缓在TM4饲养层上培养的来自11.5天妊娠龄胚胎的PGC的退化。

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