Notarangelo Luigi D, Badolato Raffaele
Division of Immunology, Children's Hospital, Harvard Medical School, 1 Blackfan Circle, Boston, MA 02115, USA.
J Leukoc Biol. 2009 Mar;85(3):335-43. doi: 10.1189/jlb.0808474. Epub 2008 Dec 16.
Leukocyte recirculation through central and peripheral lymphoid organs and peripheral tissues is essential to maintain immune homeostasis. Some of the genetically determined, primary immunodeficiencies compromise leukocyte trafficking. Here, we review the mechanisms and consequences of impaired leukocyte trafficking in leukocyte adhesion-deficiency syndromes, Warts-Hypo-gamma-globulinemia-Infections-Myelokathexis syndrome and Wiskott-Aldrich syndrome.
白细胞通过中枢和外周淋巴器官以及外周组织进行再循环对于维持免疫稳态至关重要。一些由基因决定的原发性免疫缺陷会损害白细胞的迁移。在此，我们综述白细胞黏附缺陷综合征、疣-低丙种球蛋白血症-感染-粒细胞减少综合征和威斯科特-奥尔德里奇综合征中白细胞迁移受损的机制及后果。
