Program in Cellular and Molecular Biology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Curr Opin Cell Biol. 2013 Oct;25(5):650-8. doi: 10.1016/j.ceb.2013.05.007. Epub 2013 Jun 21.
Rapid leukocyte motility is essential for immunity and host defense. There has been progress in understanding the molecular signals that regulate leukocyte motility both in vitro and in vivo. However, a gap remains in understanding how complex signals are prioritized to result in directed migration, which is critical for both adaptive and innate immune function. Here we focus on interstitial migration and how external cues are translated into intracellular signaling pathways that regulate leukocyte polarity, directional sensing and motility in three-dimensional spaces.
白细胞的快速运动对于免疫和宿主防御至关重要。目前，人们在理解调控白细胞运动的分子信号方面已经取得了一些进展，无论是在体外还是在体内。然而，人们对于复杂信号如何被优先处理以导致定向迁移的理解仍然存在差距，而定向迁移对于适应性免疫和固有免疫功能都至关重要。在这里，我们重点关注细胞间质迁移以及外部线索如何转化为细胞内信号通路，从而调节白细胞在三维空间中的极性、定向感应和运动。
