人异种移植模型作为评估前列腺癌新型疗法潜力的有用工具。
Human xenograft models as useful tools to assess the potential of novel therapeutics in prostate cancer.
作者信息
van Weerden W M, Bangma C, de Wit R
机构信息
Department of Urology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands.
出版信息
Br J Cancer. 2009 Jan 13;100(1):13-8. doi: 10.1038/sj.bjc.6604822. Epub 2008 Dec 16.
Abstract
With docetaxel as effective chemotherapy for hormone refractory prostate cancer (HRPC), the number of new treatment combinations for HRPC is expanding demanding a fast-track screening system. This review elaborates on the use of xenograft models to select the most promising combination therapies for entering into phase II clinical trials.
摘要
多西他赛作为激素难治性前列腺癌（HRPC）的有效化疗药物，HRPC新治疗组合的数量不断增加，这就需要一个快速筛选系统。本综述阐述了异种移植模型在选择最有前景的联合疗法以进入II期临床试验中的应用。
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