[Apoptosis induced by granzyme B].

作者信息

Sintsov A V, Kovalenko E I, Khanin M A

机构信息

Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 119991 Russia.

出版信息

Bioorg Khim. 2008 Nov-Dec;34(6):725-33. doi: 10.1134/s1068162008060010.

DOI:10.1134/s1068162008060010

PMID:19088744

Abstract

Results of biochemical studies of apoptosis reactions induced by granzyme B are considered and summarized. Special attention is paid to the reactions of procaspase activation and limited proteolysis of apoptotic targets. Found values of kinetic constants of granzyme B-mediated enzymatic reactions are listed.

摘要