Elguezabal N, Maza J L, Dorronsoro S, Pontón J
Department of Inmunología, Microbiología y Parasitología, Facultad de Medicina y Odontología, Universidad del PaísVasco, Spain.
Open Dent J. 2008;2:1-4. doi: 10.2174/1874210600802010001. Epub 2008 Jan 8.
Adhesion of Candida albicans to acrylic of dental prostheses or to salivary macromolecules adsorbed on their surface is believed to be a critical event in the development of denture stomatitis. In previous studies our group has shown that adhesion of C. albicans germ tubes to polystyrene is decreased by saliva whereas C. albicans yeast cells adhesion to the same material is enhanced. The results presented in this study confirm this dual role played by whole saliva, since it decreased the adhesion of germ tubes but increased the adhesion of yeast cells to polymethylmetacrylate (PMMA). These effects mediated by whole saliva do not seem to be related to an inhibition of the germination of C. albicans, since similar levels of filamentation were observed in presence and absence of saliva. These results may give new insights into the conflicting role of saliva in the adhesion of C. albicans to acrylic resins of dental prostheses.
白色念珠菌黏附于假牙的丙烯酸树脂或其表面吸附的唾液大分子被认为是义齿性口炎发展过程中的关键事件。在之前的研究中，我们小组已经表明，唾液可降低白色念珠菌芽管对聚苯乙烯的黏附，而白色念珠菌酵母细胞对相同材料的黏附则增强。本研究呈现的结果证实了全唾液所起的这种双重作用，因为它降低了芽管的黏附，但增加了酵母细胞对聚甲基丙烯酸甲酯（PMMA）的黏附。全唾液介导的这些作用似乎与抑制白色念珠菌的萌发无关，因为在有唾液和无唾液的情况下观察到了相似程度的菌丝形成。这些结果可能为唾液在白色念珠菌黏附于假牙丙烯酸树脂过程中的矛盾作用提供新的见解。
