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双组分调控系统VicRK对马链球菌兽疫亚种的毒力很重要。

The Two-Component Regulatory System VicRK is Important to Virulence of Streptococcus equi Subspecies equi.

作者信息

Liu Mengyao, McClure Michael J, Zhu Hui, Xie Gang, Lei Benfang

机构信息

Department of Veterinary Molecular Biology, Montana State University, Bozeman, Montana 59717, USA.

出版信息

Open Microbiol J. 2008;2:89-93. doi: 10.2174/1874285800802010089. Epub 2008 Jun 19.

DOI:10.2174/1874285800802010089
PMID:19088917
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2593050/
Abstract

This study aims at evaluating the importance of the two-component regulatory system VicRK to virulence of the horse pathogen Streptococcus equi subspecies equi and the potential of a vicK mutant as a live vaccine candidate using mouse infection models. The vicK gene was deleted by gene replacement. The DeltavicK mutant is attenuated in virulence in both subcutaneous and intranasal infections in mice. DeltavicK grows less slowly than the parent strain but retains the ability of S. equi to resist to phagocytosis by polymorphoneuclear leukocytes, suggesting that the vicK deletion causes growth defect. DeltavicK infection protects mice against reinfection with a wild-type S. equi strain. Intranasal DeltavicK infection induces production of anti-SeM mucosal IgA and systemic IgG. These results indicate that VicRK is important to S. equi growth and virulence and suggest that DeltavicK has the potential to be developed as a live S. equi vaccine.

摘要

本研究旨在利用小鼠感染模型评估双组分调控系统VicRK对马病原菌马链球菌马亚种毒力的重要性，以及vicK突变体作为活疫苗候选株的潜力。通过基因置换缺失了vicK基因。ΔvicK突变体在小鼠皮下和鼻内感染中的毒力均减弱。ΔvicK的生长速度比亲本菌株慢，但保留了马链球菌抵抗多形核白细胞吞噬的能力，这表明vicK缺失导致生长缺陷。ΔvicK感染可保护小鼠免受野生型马链球菌菌株的再次感染。鼻内ΔvicK感染可诱导抗SeM黏膜IgA和全身性IgG的产生。这些结果表明，VicRK对马链球菌的生长和毒力很重要，并表明ΔvicK有潜力被开发为马链球菌活疫苗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/2593050/04c0bd0a8213/TOMICROJ-2-89_F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/2593050/07778d1bf25c/TOMICROJ-2-89_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/2593050/1508b3ea05ac/TOMICROJ-2-89_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/2593050/671747b4d58b/TOMICROJ-2-89_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/2593050/6de6d3a8f475/TOMICROJ-2-89_F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/2593050/04c0bd0a8213/TOMICROJ-2-89_F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/2593050/07778d1bf25c/TOMICROJ-2-89_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/2593050/1508b3ea05ac/TOMICROJ-2-89_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/2593050/671747b4d58b/TOMICROJ-2-89_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/2593050/6de6d3a8f475/TOMICROJ-2-89_F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/2593050/04c0bd0a8213/TOMICROJ-2-89_F5.jpg

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