MicAB双组分信号系统参与肺炎链球菌的毒力作用。
The MicAB two-component signaling system is involved in virulence of Streptococcus pneumoniae.
作者信息
Kadioglu Aras, Echenique Josè, Manco Sonia, Trombe Marie-Claude, Andrew Peter W
机构信息
Department of Microbiology and Immunology, University of Leicester, Leicester LE1 9HN, United Kingdom.
出版信息
Infect Immun. 2003 Nov;71(11):6676-9. doi: 10.1128/IAI.71.11.6676-6679.2003.
Abstract
In Streptococcus pneumoniae, the two-component signaling system MicAB was previously shown to contribute to repression of competence when oxygen is limited. In virulent strains expressing the serotype 2 and 6 capsule, mutation of the MicB kinase reduced the lag period of growth when cultures were switched from an aerobic to anaerobic atmosphere. After intranasal challenge of mice, the micB::km mutation decreased virulence, as shown by the absence of symptoms and by a lower level of recovery of CFU from lungs and blood. It is proposed that MicAB is involved in the adaptive response of the bacteria to changes in oxygen level during the course of infection.
摘要
在肺炎链球菌中，双组分信号系统MicAB先前已被证明在氧气受限的情况下有助于抑制感受态。在表达2型和6型荚膜的有毒菌株中，当培养物从需氧环境切换到厌氧环境时，MicB激酶的突变缩短了生长延迟期。经鼻内感染小鼠后，micB::km突变降低了毒力，表现为无症状以及从肺和血液中回收的CFU水平较低。有人提出，MicAB参与了细菌在感染过程中对氧水平变化的适应性反应。
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