含石榴提取物凝胶的抗牙菌斑和抗牙龈炎作用：一项人体双盲临床研究
Antiplaque and antigingivitis effects of a gel containing Punica granatum Linn extract: a double-blind clinical study in humans.
作者信息
Salgado Alexandre Daher Yunes, Maia Juliana Lemos, Pereira Sérgio Luís da Silva, de Lemos Telma Leda Gomes, Mota Olívia Morais de Lima
机构信息
University of Fortaleza, CE, Brazil.
出版信息
J Appl Oral Sci. 2006 Jun;14(3):162-6. doi: 10.1590/s1678-77572006000300003.
OBJECTIVES
The antiplaque and antigingivitis effects of a gel containing 10% Punica granatum Linn extract were evaluated using a 21-day partial-mouth experimental model of gingivitis.
METHODS
23 volunteers participated in this cross-over, double-blind study, carried out in 2 phases of 21 days each. For each period of the experiment, an acrylic toothshield was made for each volunteer to carry the test or placebo gel as well as to avoid brushing of the 4 experimental teeth (posterior teeth in the lower left quadrant). The subjects were randomly assigned to use either the placebo gel (control group) or the test gel (experimental group) and were instructed to brush the remaining teeth normally 3 times a day. On days 0 and 21, the visible plaque index (VPI) and gingival bleeding index (GBI) were recorded.
RESULTS
The results did not show statistically significant difference between control and experimental groups for either of the indices (VPI and GBI).
CONCLUSION
The gel containing 10% Punica granatum Linn extract was not efficient in preventing supragingival dental plaque formation and gingivitis.
目的
采用为期21天的牙龈炎部分口腔实验模型，评估含10%石榴提取物凝胶的抗牙菌斑和抗牙龈炎效果。
方法
23名志愿者参与了这项交叉双盲研究，研究分两个阶段进行，每个阶段为期21天。在实验的每个阶段，为每位志愿者制作一个丙烯酸牙托，用于携带测试凝胶或安慰剂凝胶，同时避免刷4颗实验牙齿（左下象限的后牙）。受试者被随机分配使用安慰剂凝胶（对照组）或测试凝胶（实验组），并被指示每天正常刷牙3次，刷其余牙齿。在第0天和第21天，记录可见牙菌斑指数（VPI）和牙龈出血指数（GBI）。
结果
两组在任一指数（VPI和GBI）上均未显示出统计学上的显著差异。
结论
含10%石榴提取物的凝胶在预防龈上牙菌斑形成和牙龈炎方面效果不佳。
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