巴西药用植物、天然萘醌及其类似物对耐甲氧西林金黄色葡萄球菌的体外活性。

In vitro activity of Brazilian medicinal plants, naturally occurring naphthoquinones and their analogues, against methicillin-resistant Staphylococcus aureus.

作者信息

Machado T B, Pinto A V, Pinto M C F R, Leal I C R, Silva M G, Amaral A C F, Kuster R M, Netto-dosSantos K R

机构信息

Núleo de Pesquisas de Productos Naturais, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

出版信息

Int J Antimicrob Agents. 2003 Mar;21(3):279-84. doi: 10.1016/s0924-8579(02)00349-7.

DOI:10.1016/s0924-8579(02)00349-7

PMID:12636992

Abstract

Fourteen extracts from Brazilian traditional medicinal plants used to treat infectious diseases were used to look for potential antimicrobial activity against multiresistant bacteria of medical importance. Staphylococcus aureus strains were susceptible to extracts of Punica granatum and Tabebuia avellanedae. The minimum inhibitory concentrations (MICs) of the total extracts and of additional fractions of these plants were determined by employing strains of methicillin-resistant (MRSA) and -sensitive (MSSA) S. aureus, including isolates of the PFGE clone A, which is prevalent in Brazil and two ATCC reference strains. A mixture of ellagitannins isolated from P. granatum and two naphthoquinones isolated from T. avellanedae demonstrated antibacterial activity against all S. aureus strains tested. Semi-synthetic furanonaphthoquinones (FNQs) showed lower MICs than those exhibited by natural occurring naphthoquinones. The results indicate that these natural products can be effective potential candidates for the development of new strategies to treat MRSA infections.

摘要

从用于治疗传染病的巴西传统药用植物中提取的14种提取物，被用于寻找针对具有医学重要性的多重耐药细菌的潜在抗菌活性。金黄色葡萄球菌菌株对石榴（Punica granatum）和阿维拉纳塔贝布树（Tabebuia avellanedae）的提取物敏感。通过使用耐甲氧西林（MRSA）和对甲氧西林敏感（MSSA）的金黄色葡萄球菌菌株，包括在巴西流行的PFGE克隆A的分离株以及两种ATCC参考菌株，测定了这些植物总提取物及其其他组分的最低抑菌浓度（MIC）。从石榴中分离出的鞣花单宁混合物以及从阿维拉纳塔贝布树中分离出的两种萘醌，对所有测试的金黄色葡萄球菌菌株均表现出抗菌活性。半合成呋喃萘醌（FNQ）的MIC低于天然萘醌。结果表明，这些天然产物可能是开发治疗MRSA感染新策略的有效潜在候选物。