Hod I, Herz A, Zimber A
Am J Pathol. 1977 Mar;86(3):545-58.
Lung carcinoma of sheep (Jaagsiekte) is a bronchiolar-alveolar cell carcinoma. Differences in the ultrastructural patterns of early and advanced lesions of the disease are described. A-type and C-type viruses were observed in advanced tumors and were absent in early lesions. Numerous microtubules were characteristic in the epithelial tumor cells of the early lesions and were absent in the advanced tumor. In comparison to the early lesions, extensive cytosome production, surfactant secretion, and glycogen accumulation were observed in the advanced tumor. The immune response to the early tumor lesion was restricted to the peribronchiolar lymph aggregates, while in the advanced stages of the disease the systemic immune response was markedly increased.
绵羊肺癌（羊肺腺瘤病）是一种细支气管肺泡细胞癌。本文描述了该疾病早期和晚期病变超微结构模式的差异。在晚期肿瘤中观察到A 型和C 型病毒，而早期病变中不存在。大量微管是早期病变上皮肿瘤细胞的特征，晚期肿瘤中则不存在。与早期病变相比，晚期肿瘤中观察到广泛的胞质体产生、表面活性剂分泌和糖原积累。对早期肿瘤病变的免疫反应局限于细支气管周围淋巴聚集物，而在疾病晚期全身免疫反应明显增强。
