Ortín A, Benito A A, Lacasta D, Ferrer L M, De Las Heras M
Departamento de Patología Animal, Universidad de Zaragoza, C/Miguel Servet 177, 50013 Zaragoza, Spain.
Vet Pathol. 2007 Sep;44(5):710-2. doi: 10.1354/vp.44-5-710.
A spontaneous lung tumor in a 5-year-old goat of the Murciano-Granadina breed is described in this paper. Clinical signs of cachexia and tachypnoea were evident, and a considerable amount of white mucous foamy fluid was discharged from the nostrils when the animal's head was lowered. A lung tumor with the characteristics of bronchioloalveolar carcinoma was detected during histopathologic examination. The tumor cells were positive for surfactant proteins C and B, confirming that alveolar type II cells were the origin of the neoplasia. Tumor samples were tested by polymerase chain reaction, immunoblotting, and immunohistochemistry for the presence of Jaagsiekte sheep retrovirus (JSRV) and enzootic nasal tumor virus (ENTV), another retrovirus very closely related to JSRV, but all tests were negative. Therefore, this is the first reported case of spontaneous bronchioloalveolar carcinoma not related to JSRV or ENTV infection in a goat.
本文描述了一只5岁穆尔西亚诺-格拉纳迪纳品种山羊的自发性肺肿瘤。恶病质和呼吸急促的临床症状明显，当动物头部低垂时，鼻孔会排出大量白色黏液泡沫状液体。在组织病理学检查中发现了具有细支气管肺泡癌特征的肺肿瘤。肿瘤细胞表面活性蛋白C和B呈阳性，证实肿瘤起源于II型肺泡细胞。通过聚合酶链反应、免疫印迹和免疫组织化学对肿瘤样本进行检测，以确定是否存在绵羊肺腺瘤病毒（JSRV）和地方流行性鼻肿瘤病毒（ENTV，另一种与JSRV密切相关的逆转录病毒），但所有检测均为阴性。因此，这是首次报道的山羊自发性细支气管肺泡癌病例，且该病例与JSRV或ENTV感染无关。
