用于再生医学的干细胞来源。

Stem cell sources for regenerative medicine.

作者信息

Riazi Ali M, Kwon Sarah Y, Stanford William L

机构信息

Department of Chemical Engineering, University of Toronto, Toronto, Ontario, Canada.

出版信息

Methods Mol Biol. 2009;482:55-90. doi: 10.1007/978-1-59745-060-7_5.

DOI:10.1007/978-1-59745-060-7_5

PMID:19089350

Abstract

Tissue-resident stem cells or primitive progenitors play an integral role in homeostasis of most organ systems. Recent developments in methodologies to isolate and culture embryonic and somatic stem cells have many new applications poised for clinical and preclinical trials, which will enable the potential of regenerative medicine to be realized. Here, we overview the current progress in therapeutic applications of various stem cells and discuss technical and social hurdles that must be overcome for their potential to be realized.

摘要

组织驻留干细胞或原始祖细胞在大多数器官系统的稳态中发挥着不可或缺的作用。分离和培养胚胎干细胞与成体干细胞方法的最新进展，有许多新应用正准备用于临床试验和临床前试验，这将使再生医学的潜力得以实现。在此，我们概述了各种干细胞治疗应用的当前进展，并讨论了要实现其潜力必须克服的技术和社会障碍。