Tohgi H, Abe T, Takahashi S, Nozaki Y, Kikuchi T
Department of Neurology, Iwate Medical University, Morioka, Japan.
Neurosci Lett. 1991 Jun 24;127(2):212-4. doi: 10.1016/0304-3940(91)90796-v.
We determined the concentrations of tyrosine, L-3,4-dihydroxyphenylalanine (DOPA), dopamine (DA), and 3-O-methyldopa (3-OMD) in the cerebrospinal fluid (CSF) of parkinsonian patients and elevated potential interactions between the substances. We found a significant increase in tyrosine, and a significant decrease in DOPA, DA, and 3-OMD. We also found that for a given concentration of DOPA, DA and 3-OMD were proportional. In addition, the ratio of DA to 3-OMD was significantly shifted in favor of DA in parkinsonian patients.
我们测定了帕金森病患者脑脊液（CSF）中酪氨酸、L-3,4-二羟基苯丙氨酸（多巴）、多巴胺（DA）和3-O-甲基多巴（3-OMD）的浓度，并研究了这些物质之间可能存在的相互作用增强情况。我们发现酪氨酸显著增加，而多巴、多巴胺和3-OMD显著减少。我们还发现，在给定的多巴浓度下，多巴胺和3-OMD呈比例关系。此外，帕金森病患者中多巴胺与3-OMD的比例明显向有利于多巴胺的方向偏移。
