Mineev K K, Prakhova L N, Il'ves A G, Kataeva G V, Petrov A M, Reznikova T N, Pozdnyakov A V, Stolyarov I D
Institute of the Human Brain, Russian Academy of Sciences, St. Petersburg, Russia.
Neurosci Behav Physiol. 2009 Jan;39(1):35-8. doi: 10.1007/s11055-008-9086-2.
A total of 65 patients with clinically significant diagnoses of remitting multiple sclerosis in the stage of remission were studied. Neurological status was investigated with assessment on the FS and EDSS scales, with neuropsychological testing, and MRI scans (1.5 T). The severity of brain atrophy (in terms of the parenchyma volume) and the total volume of foci on T2 images were assessed as proportions of intracerebral volume. The severity of neurological deficit depended on the volume of intratentorial focal lesions and the level of brain atrophy. Cognitive disorders were identified in 89% of patients, and the severity of these was associated with the level of atrophy and the volume of foci on T2 images in the dominant hemisphere.
共研究了65例处于缓解期的临床诊断为缓解型多发性硬化症的患者。通过FS和EDSS量表评估、神经心理学测试以及MRI扫描（1.5T）来调查神经学状态。脑萎缩的严重程度（以实质体积衡量）和T2图像上病灶的总体积以脑内体积的比例进行评估。神经功能缺损的严重程度取决于幕下局灶性病变的体积和脑萎缩程度。89%的患者存在认知障碍，其严重程度与萎缩程度以及优势半球T2图像上病灶的体积相关。
