Paty D W
Department of Medicine, Vancouver General Hospital, British Columbia, Canada.
Can J Neurol Sci. 1988 Aug;15(3):266-72. doi: 10.1017/s0317167100027724.
Magnetic resonance imaging (MRI) has been shown to be a good method of visualizing the lesions in MS. We have studied several applications of MRI to the evaluation of patients and experimental models. In diagnosis, MRI is the most sensitive test for the demonstration of dissemination of lesions in space. Pathological correlation studies show that MRI reliably measures the extent of chronic demyelination. Experimental studies show that MRI detects acute inflammatory lesions and measures their evolution. MRI also is a reliable measure of the extent of the MS process, serial MRI scans detect evidence of disease activity in MS not always disclosed by clinical evaluation. MRI will have an enormous future impact on the evaluation of patients in clinical studies and in understanding the evolution of pathological processes.
磁共振成像（MRI）已被证明是可视化多发性硬化症（MS）病变的良好方法。我们研究了MRI在患者评估和实验模型中的多种应用。在诊断方面，MRI是显示病变在空间上播散的最敏感检查。病理相关性研究表明，MRI能可靠地测量慢性脱髓鞘的范围。实验研究表明，MRI能检测急性炎症性病变并测量其演变过程。MRI也是衡量MS疾病进程范围的可靠指标，系列MRI扫描能检测出临床评估不一定能发现的MS疾病活动证据。MRI在临床研究中对患者评估以及理解病理过程的演变方面将产生巨大的未来影响。
