Srivastava S, Lundqvist A, Childs R W
National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Cytotherapy. 2008;10(8):775-83. doi: 10.1080/14653240802648181.
Recently there has been a substantial gain in our understanding of the role NK-cells play in mediating innate host immune responses. Although NK cells have long been known to mediate antigen independent tumor cytotoxicity, the therapeutic potential of NK cell-based immunotherapy has yet to be realized. Manipulating the balance between inhibitory and activating NK receptor signals, sensitization of tumor target cells to NK cell-mediated apoptosis, and recent discoveries in NK-cell receptor biology have fueled translational research that has led to clinical trials investigating a number of novel methods to potentiate NK cytotoxicity against human malignancies.
最近，我们对自然杀伤（NK）细胞在介导先天性宿主免疫反应中所起作用的理解有了显著进展。尽管NK细胞长期以来一直被认为可介导不依赖抗原的肿瘤细胞毒性，但基于NK细胞的免疫疗法的治疗潜力尚未得到充分发挥。调节抑制性和激活性NK受体信号之间的平衡、使肿瘤靶细胞对NK细胞介导的凋亡敏感化，以及NK细胞受体生物学的最新发现推动了转化研究，这些研究已促成了多项临床试验，旨在探索多种增强NK细胞对人类恶性肿瘤细胞毒性的新方法。
