Jain Sanjiv, Rezo Angela, Shadbolt Bruce, Dahlstrom Jane E
Department of Anatomical Pathology, Canberra Hospital, Canberra, Australia.
Pathology. 2009 Jan;41(1):57-67. doi: 10.1080/00313020802563502.
Interest in the presence and management of synchronous multiple ipsilateral breast cancer has been reported since the early 1920s. The demonstration of multiple foci of breast cancer has been reported in 9-75% of breast cancer related specimens. The large difference in reported incidence is multifactorial and related to the definitions applied, mode of detection and pathological assessment. However, randomised clinical trials comparing total mastectomy and segmental mastectomy with or without radiation over many years have shown no difference in distant disease-free survival or overall survival in patients with synchronous multiple ipsilateral breast cancer compared with unifocal breast cancer. This review examines the current definitions, incidence, pathological assessment, staging and surgical options of synchronous multiple ipsilateral breast cancer.
自20世纪20年代初以来，人们就对同侧多原发性乳腺癌的存在及治疗产生了兴趣。在9%至75%的乳腺癌相关标本中发现了多个乳腺癌病灶。报告发病率的巨大差异是多因素的，与所采用的定义、检测方式和病理评估有关。然而，多年来比较全乳切除术和节段性乳房切除术（加或不加放疗）的随机临床试验表明，与单灶性乳腺癌患者相比，同侧多原发性乳腺癌患者的远处无病生存率或总生存率没有差异。本综述探讨了同侧多原发性乳腺癌的当前定义、发病率、病理评估、分期和手术选择。
