[β-内酰胺类抗生素与舒巴坦联合应用对肠杆菌科细菌、铜绿假单胞菌和不动杆菌的体外活性。一项多中心研究的结果]
[In vitro activity of beta-lactam antibiotics in combination with sulbactam against enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter. Results of a multicenter study].
作者信息
Kazmierczak A, Siebor E, Acar J F, Denis F, Drugeon H, Fleurette J, Sirot J, Soussy C J, Thabaut A
机构信息
Laboratoire de Bactériologie, Centre Hospitalier Universitaire, Dijon.
出版信息
Pathol Biol (Paris). 1991 May;39(5):384-90.
The in vitro antimicrobial activity of ticarcillin (TICAR), mezlocillin (MEZLO), piperacillin (PIPER), cefoperazone (CPZ), cefotaxime (CTX) and ceftazidime (CAZ), alone and in combination with 8 micrograms/ml of sulbactam (SULB), was studied by agar dilution against TICAR resistant strains isolated in 8 hospitals over a period of 3 months in 1989 (747 enterobacteria, 110 Ps. aeruginosa and 48 Acinetobacter sp.). SULB did not modify the activity of beta-lactam antibiotics against Ps. aeruginosa. The 6 beta-lactam antibiotics SULB combinations were only active for 27% of Acinetobacter SULB sensitive. SULB restored the activity of: MEZLO, PIPER, CPZ in Enterobacteria producing a penicillinase; PIPER, CTX and CAZ in Enterobacteria producing a broad-spectrum beta-lactamase; MEZLO, PIPER, CTX and CAZ in M. morganii producing a derepressed cephalosporinase.
1989年，在3个月的时间里，采用琼脂稀释法，对从8家医院分离出的替卡西林（TICAR）耐药菌株，研究了替卡西林（TICAR）、美洛西林（MEZLO）、哌拉西林（PIPER）、头孢哌酮（CPZ）、头孢噻肟（CTX）和头孢他啶（CAZ）单独及与8微克/毫升舒巴坦（SULB）联合使用时的体外抗菌活性（747株肠杆菌、110株铜绿假单胞菌和48株不动杆菌属）。舒巴坦未改变β-内酰胺类抗生素对铜绿假单胞菌的活性。6种β-内酰胺抗生素与舒巴坦的组合仅对27%的对舒巴坦敏感的不动杆菌有活性。舒巴坦恢复了以下菌株中相应抗生素的活性：在产生青霉素酶的肠杆菌中恢复了美洛西林、哌拉西林、头孢哌酮的活性；在产生广谱β-内酰胺酶的肠杆菌中恢复了哌拉西林、头孢噻肟和头孢他啶的活性；在产生去阻遏头孢菌素酶的摩根氏菌中恢复了美洛西林、哌拉西林、头孢噻肟和头孢他啶的活性。
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