弗林德洛尔斯A - C：来自弗林德西亚属植物的抗疟双吲哚生物碱。
Flinderoles A-C: antimalarial bis-indole alkaloids from Flindersia species.
作者信息
Fernandez Liza S, Buchanan Malcolm S, Carroll Anthony R, Feng Yun Jiang, Quinn Ronald J, Avery Vicky M
机构信息
Eskitis Institute, Griffith University, Brisbane, QLD 4111 Australia.
出版信息
Org Lett. 2009 Jan 15;11(2):329-32. doi: 10.1021/ol802506n.
With the aim of finding new natural product antimalarials, the novel indole alkaloids flinderole A-C were found to have selective antimalarial activities with IC(50) values between 0.15-1.42 microM. Flinderole A was isolated from the Australian plant Flindersia acuminata and flinderoles B and C from the Papua New Guinean plant F. amboinensis. Flinderoles A-C contain an unprecedented rearranged skeleton compared to their related isomers of the borreverine class of compounds.
为了寻找新的天然产物抗疟药，发现新型吲哚生物碱弗林德洛A - C具有选择性抗疟活性，IC（50）值在0.15 - 1.42微摩尔之间。弗林德洛A是从澳大利亚植物尖叶弗林德木中分离得到的，而弗林德洛B和C则是从巴布亚新几内亚植物安汶弗林德木中分离得到的。与相关的博雷维林类化合物异构体相比，弗林德洛A - C含有一个前所未有的重排骨架。
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