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手性固定相 HPLC 和环糊精选择剂 CE 对手性二萜 flinderoles 和 borreverines 的拆分

Enantioseparation of flinderoles and borreverines by HPLC on Chirobiotic V and V2 stationary phases and by CE using cyclodextrin selectors.

机构信息

Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX, 76019, USA.

出版信息

Anal Bioanal Chem. 2013 Nov;405(28):9169-77. doi: 10.1007/s00216-013-7335-x. Epub 2013 Sep 17.

DOI:10.1007/s00216-013-7335-x
PMID:24043376
Abstract

Racemic mixtures of the promising anti-malarial bisindole alkoids, flinderole A-C, desmethyl flinderole C, borreverine and isoborreverine, are baseline-separated for the first time by HPLC using vancomycin-based stationary phases and partially separated by capillary electrophoresis (CE) using cyclodextrin selectors. The HPLC results compare the performance of Chirobiotic V and V2 in the polar organic and reversed phase modes and their complementary selectivity is discussed. The performance of the cyclodextrin selectors in CE, while less effective, are discussed in terms of their selectivity in normal and reversed polarity modes.

摘要

手性混合物的有前途的抗疟双吲哚烷生物碱，flinderole A-C，desmethyl flinderole C，borreverine 和异博雷定，首次通过 HPLC 用万古霉素为基础的固定相进行基线分离，并通过使用环糊精选择器的毛细管电泳（CE）部分分离。HPLC 结果比较了 Chirobiotic V 和 V2 在极性有机和反相模式下的性能，并讨论了它们的互补选择性。虽然环糊精选择器在 CE 中的性能较差，但讨论了它们在正常和反相极性模式下的选择性。

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