皮门冬胺 A-C，从澳大利亚树 Flindersia pimenteliana 的叶子中分离出的吲哚生物碱。
Pimentelamines A-C, Indole Alkaloids Isolated from the Leaves of the Australian Tree Flindersia pimenteliana.
机构信息
Environmental Futures Research Institute, Griffith University , Southport 4222, Gold Coast, Australia.
Griffith Institute for Drug Discovery, Griffith University , Nathan 4111, Brisbane, Australia.
出版信息
J Nat Prod. 2017 Dec 22;80(12):3211-3217. doi: 10.1021/acs.jnatprod.7b00587. Epub 2017 Dec 13.
Three members of a new class of ascorbic acid-adduct indole alkaloids (1-3), a new prenylated indole alkaloid (4), and five known compounds (5-9) were isolated from the leaves of Flindersia pimenteliana. The structures of 1-4 were elucidated on the basis of their (+)-HRESIMS and 2D NMR spectroscopic data. Antiplasmodial activity was also reported for the natural products against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum with IC values ranging from 0.19 to 3.6 μM.
从 Flindersia pimenteliana 的叶子中分离得到了三种新型抗坏血酸加成吲哚生物碱（1-3）、一种新的香叶基吲哚生物碱（4）和五种已知化合物（5-9）。基于 (+)-HRESIMS 和 2D NMR 光谱数据确定了 1-4 的结构。天然产物对氯喹敏感（3D7）和氯喹耐药（Dd2）疟原虫也表现出抗疟原虫活性，IC 值范围为 0.19 至 3.6 μM。
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