Hernandez Maria D, Mansouri Mohammad D, Aslam Saima, Zeluff Barry, Darouiche Rabih O
Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA.
Infect Control Hosp Epidemiol. 2009 Feb;30(2):190-2. doi: 10.1086/593205.
We assessed the in vitro antimicrobial activity and the in vivo efficacy of dipping ventricular assist devices in a combination of N-acetylcysteine, gentamicin, and amphotericin B (NAC/G/A). Ventricular assist devices dipped in NAC/G/A exhibited broad-spectrum antimicrobial activity in vitro and were less likely than undipped devices to become colonized with Staphylococcus aureus in a rabbit model.
我们评估了将心室辅助装置浸入N-乙酰半胱氨酸、庆大霉素和两性霉素B（NAC/G/A）的组合中时的体外抗菌活性和体内疗效。浸入NAC/G/A的心室辅助装置在体外表现出广谱抗菌活性，并且在兔模型中比未浸入的装置更不容易被金黄色葡萄球菌定植。
