Reis Elaine F C, Celso O R, Alves Lívia L, Ferreira Ana Paula, de Almeida Mauro V
Departamento de Química, Universidade Federal de Juiz de Fora, Juiz de Fora-MG 36036-330, Brazil.
Chem Biol Drug Des. 2008 Dec;72(6):596-8. doi: 10.1111/j.1747-0285.2008.00740.x.
In this work, we report the preparation and evaluation of the in vitro and in vivo of the immunosuppressive activity of a series of lipophilic amino alcohols and diamines. All compounds were evaluated for inhibition of cell proliferation, cytotoxicity and NO production. Compounds 9, 12, 13, 17, and 18 did not display inhibition of cell proliferation while decreased NO production. The two most potent compounds, 13 and 17, submitted to delayed-type hypersensitivity assays showed immunosuppressive activity.
