两亲性吡喃半乳糖基二胺和氨基醇作为抗结核药物的合成。
Synthesis of amphiphilic galactopyranosyl diamines and amino alcohols as antitubercular agents.
作者信息
de Almeida Mauro Vieira, Le Hyaric Mireille, Amarante Giovanni Wilson, Silva Lourenço Maria Cristina, Lima Brandão Marcelo Luiz
机构信息
Departamento de Química, Universidade Federal de Juiz de Fora, Juiz de Fora-MG 36036-330, Brazil.
出版信息
Eur J Med Chem. 2007 Aug;42(8):1076-83. doi: 10.1016/j.ejmech.2007.01.009. Epub 2007 Jan 25.
Mono- and diacylated derivatives of galactopyranosyl amines were obtained from d-galactose, via aminated intermediates prepared by reaction of 6-deoxy-6-iodo-1,2:3,4-di-O-isopropylidene-alpha-d-galactopyranose with 1,3-propanediamine, 1,2-ethanediamine or ethanolamine. Monoacylated derivatives displayed antitubercular activity.
通过6-脱氧-6-碘-1,2:3,4-二-O-异亚丙基-α-D-吡喃半乳糖与1,3-丙二胺、1,2-乙二胺或乙醇胺反应制备的胺化中间体，从D-半乳糖获得了吡喃半乳糖胺的单酰化和二酰化衍生物。单酰化衍生物显示出抗结核活性。
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