de Almeida Mauro Vieira, Le Hyaric Mireille, Amarante Giovanni Wilson, Silva Lourenço Maria Cristina, Lima Brandão Marcelo Luiz
Departamento de Química, Universidade Federal de Juiz de Fora, Juiz de Fora-MG 36036-330, Brazil.
Eur J Med Chem. 2007 Aug;42(8):1076-83. doi: 10.1016/j.ejmech.2007.01.009. Epub 2007 Jan 25.
Mono- and diacylated derivatives of galactopyranosyl amines were obtained from d-galactose, via aminated intermediates prepared by reaction of 6-deoxy-6-iodo-1,2:3,4-di-O-isopropylidene-alpha-d-galactopyranose with 1,3-propanediamine, 1,2-ethanediamine or ethanolamine. Monoacylated derivatives displayed antitubercular activity.
通过6-脱氧-6-碘-1,2:3,4-二-O-异亚丙基-α-D-吡喃半乳糖与1,3-丙二胺、1,2-乙二胺或乙醇胺反应制备的胺化中间体，从D-半乳糖获得了吡喃半乳糖胺的单酰化和二酰化衍生物。单酰化衍生物显示出抗结核活性。
