Garrido Elena, Marín Elena, González Carmen, Juzgado Diego, Boixeda Daniel, Vázquez-Sequeiros Enrique
Servicio de Gastroenterología, Hospital Universitario Ramón y Cajal, Madrid, España.
Gastroenterol Hepatol. 2008 Nov;31(9):572-5. doi: 10.1157/13128296.
Abrikosoff's tumor (AT), or granular cell tumor (GCT), is relatively rare in the gastrointestinal tract, where the most common site is the esophagus. This tumor is usually found incidentally when an upper gastrointestinal endoscopy is carried out for another reason. Endoscopically, GCT appears as a small, yellow and submucosal lesion covered by normal mucosa. Endoscopic ultrasonography shows a homogeneous hypoechoic lesion with well defined margins. The definitive diagnosis is histological. The origin of GCT is neurogenic and the tumor is composed of eosinophilic granular cytoplasm and PAS-positive cells, which show the S-100 protein on immunohistochemistry. Although GCT is usually clinically and histologically benign, some malignant cases have been reported. Consensus is lacking on the treatment and follow-up of this tumor. Currently, endoscopic mucosal resection is a safe and effective technique to treat submucosal esophageal lesions, allowing subsequent histologic analysis. We present three patients with esophageal CGT, who were definitively treated with endoscopic mucosal resection.
阿布里科索夫瘤（AT），即颗粒细胞瘤（GCT），在胃肠道中相对罕见，其中最常见的部位是食管。这种肿瘤通常在因其他原因进行上消化道内镜检查时偶然发现。在内镜下，GCT表现为一个小的、黄色的、被正常黏膜覆盖的黏膜下病变。内镜超声显示为边界清晰的均匀低回声病变。确诊依靠组织学检查。GCT起源于神经源性，肿瘤由嗜酸性颗粒状细胞质和PAS阳性细胞组成，免疫组化显示这些细胞表达S-100蛋白。虽然GCT通常在临床和组织学上为良性，但也有一些恶性病例的报道。对于该肿瘤的治疗和随访缺乏共识。目前，内镜黏膜切除术是治疗食管黏膜下病变的一种安全有效的技术，可进行后续的组织学分析。我们报告了3例食管CGT患者，他们均接受了内镜黏膜切除术的确定性治疗。
