Day Luke T, Jeanmonod Rebecca K
Department of Emergency Medicine, Albany Medical Center, Albany, NY 12207, USA.
Am J Emerg Med. 2008 Nov;26(9):1069.e1-3. doi: 10.1016/j.ajem.2008.03.028.
The serotonin syndrome is a rare toxicological emergency increasingly seen in emergency practice, secondary to increased use of proserotinergic drugs. In this case report, the condition is described in a patient taking the selective serotonin reuptake inhibitor Lexapro and the muscle-relaxant Flexeril. Based on this case, Cyclobenzaprine should be considered on the growing list of medications that can precipitate the serotonin syndrome. With the increasing prevalence of proserotinergic polypharmacy, this uncommon toxidrome should be considered by the alert emergency medicine physician.
血清素综合征是一种罕见的毒理学急症，在急诊实践中越来越常见，这是由于血清素能药物使用增加所致。在本病例报告中，描述了一名服用选择性5-羟色胺再摄取抑制剂来士普（Lexapro）和肌肉松弛剂环苯扎林（Flexeril）的患者出现的这种情况。基于该病例，在可能引发血清素综合征的药物清单不断增加的情况下，应考虑将环苯扎林列入其中。随着血清素能药物联合使用的日益普遍，警觉的急诊医学医生应考虑到这种不常见的中毒综合征。
