INVIA Medical Imaging Solutions, 3025 Boardwalk Dr. Suite 200, Ann Arbor, MI, 48108, USA.
Division of Cardiovascular Medicine, Department of Internal Medicine and Frankel Cardiovascular Center, University of Michigan, Ann Arbor, USA.
J Nucl Cardiol. 2020 Aug;27(4):1104-1113. doi: 10.1007/s12350-019-01911-9. Epub 2019 Oct 23.
Clinical use of myocardial blood flow (MBF) and flow reserve (MFR) is increasing. Motion correction is necessary to obtain accurate results but can introduce variability when performed manually. We sought to reduce that variability with an automated motion-correction algorithm.
A blinded randomized controlled trial of two technologists was performed on the motion correction of 100 dynamic Rb patient studies comparing manual motion correction with manual review and adjustment of automated motion correction. Inter-rater variability between technologists for MBF and MFR was the primary outcome with comparison made by analysis of the limits of agreement. Processing time was the secondary outcome.
Limits of agreements between the two technologists decreased significantly for both MBF and MFR, going from [- 0.22, 0.22] mL/min/g and [- 0.31, 0.36] to [- 0.12, 0.15] mL/min/g and [- 0.15, 0.18], respectively (both P < .002). In addition, the average time spent on motion correcting decreased by 1 min per study from 5:21 to 4:21 min (P = .001).
In this randomized controlled trial, the use of automated motion correction significantly decreased inter-user variability and reduced processing time.
心肌血流 (MBF) 和血流储备 (MFR) 的临床应用正在增加。为了获得准确的结果，需要进行运动校正，但手动进行运动校正可能会引入变异性。我们试图通过自动运动校正算法来减少这种变异性。
对 100 例动态 Rb 患者研究进行了两名技术员的盲法随机对照试验，比较了手动运动校正与手动审查和自动运动校正的调整。MBF 和 MFR 的技术员之间的组内变异性是主要结果，通过分析一致性界限进行比较。处理时间是次要结果。
两名技术员之间的 MBF 和 MFR 的一致性界限显著降低，从[-0.22, 0.22] mL/min/g 和[-0.31, 0.36]分别降至[-0.12, 0.15] mL/min/g 和[-0.15, 0.18] (均 P<0.002)。此外，每例研究的运动校正时间平均减少了 1 分钟，从 5:21 降至 4:21 分钟 (P=0.001)。
在这项随机对照试验中，使用自动运动校正显著降低了用户之间的变异性，并减少了处理时间。
