Baizabal-Carvallo José Fidel, Delgadillo-Márquez German, Estañol Bruno, García-Ramos Guillermo
Department of Neurology and Psychiatry, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Eur Neurol. 2009;61(3):143-8. doi: 10.1159/000186504. Epub 2008 Dec 18.
The meningitides are rare but well-identified complications in patients with systemic lupus erythematosus (SLE).
To determine the clinical characteristics, risk factors, prevalence and outcomes of the meningitides (septic and aseptic) in patients with SLE.
From January 1988 to December 2006, we identified patients with SLE and septic or aseptic meningitis.
We identified 25 episodes of meningitis in 23 patients with SLE, from a total of 1,411 SLE patients (1.63%); in 15 out of 25 episodes, a microorganism was identified. Mycobacterium tuberculosis, Listeria monocytogenes and Criptococcus neoformans represented the main microorganisms. In 10 episodes, aseptic meningitis was diagnosed. Lymphopenia, steroid use, chronic damage and systemic activity of SLE were frequent in both kinds of meningitis. Although the clinical presentation did not differ significantly, patients with septic meningitis had more residual neurological deficits (p = 0.04).
Meningitis was observed in about 1.6% of the patients with SLE; in 40% of the cases, no microorganism could be isolated. A residual neurological deficit was more common in patients with septic meningitis.
脑膜炎是系统性红斑狼疮（SLE）患者中罕见但已明确的并发症。
确定SLE患者中脑膜炎（化脓性和无菌性）的临床特征、危险因素、患病率及转归。
1988年1月至2006年12月，我们确定了患有SLE及化脓性或无菌性脑膜炎的患者。
在1411例SLE患者中，我们确定了23例患者发生25次脑膜炎发作（1.63%）；25次发作中有15次鉴定出微生物。结核分枝杆菌、单核细胞增生李斯特菌和新型隐球菌是主要微生物。10次发作诊断为无菌性脑膜炎。淋巴细胞减少、使用类固醇、慢性损害和SLE的全身活动在两种脑膜炎中均很常见。虽然临床表现无显著差异，但化脓性脑膜炎患者有更多的神经功能缺损残留（p = 0.04）。
约1.6%的SLE患者发生脑膜炎；40%的病例未分离出微生物。化脓性脑膜炎患者神经功能缺损残留更常见。
