Cecoli F, Andraghetti G, Ghiara C, Briatore L, Cavallero D, Mussap M, Minuto F, Giusti M
Department of Endocrinological and Metabolic Sciences, San Martino Hospital and University of Genoa, Genoa, Italy.
J Endocrinol Invest. 2008 Oct;31(10):888-92. doi: 10.1007/BF03346437.
Some extra-thyroid effects of TSH have been described in vitro and in vivo. TSH has recently been suggested to induce interleukin-6 secretion by adipocytes. Leptin is the main protein secreted by adipose tissue.
The aim of our study was to evaluate the acute effect of the recombinant human TSH (rhTSH)-induced TSH surge on serum leptin levels in thyroidectomized patients undergoing levothyroxine (L-T4) suppressive therapy for differentiated thyroid carcinoma (DTC).
A cohort of 15 female DTC patients was evaluated. Standard rhTSH testing was performed. Leptin, TSH, thyroid hormones, and thyroglobulin were measured before and 3, 6, and 9 days after rhTSH testing. Some metabolic parameters were also evaluated at the baseline.
Baseline leptin levels were 12.2+/-3.2 microg/l. Only body mass index (BMI) correlated significantly (p<0.05) with leptin levels. After rhTSH administration, TSH levels increased significantly (p<0.001), while thyroid hormones remained unchanged. Twenty hours after the last rhTSH administration, leptin (11.8+/-3.0 microg/l) levels were unchanged. The maximal TSH level was negatively related with BMI (p<0.05), but no correlation between maximal TSH and leptin levels after rhTSH was noted.
Our in vivo experimental model suggests that an acute TSH increase after rhTSH testing is ineffective in changing circulating leptin levels.
促甲状腺激素（TSH）的一些甲状腺外效应已在体外和体内得到描述。最近有人提出TSH可诱导脂肪细胞分泌白细胞介素-6。瘦素是脂肪组织分泌的主要蛋白质。
我们研究的目的是评估重组人TSH（rhTSH）诱导的TSH激增对接受左甲状腺素（L-T4）抑制治疗的分化型甲状腺癌（DTC）甲状腺切除患者血清瘦素水平的急性影响。
对15名女性DTC患者进行了队列研究。进行了标准的rhTSH检测。在rhTSH检测前以及检测后3、6和9天测量瘦素、TSH、甲状腺激素和甲状腺球蛋白。还在基线时评估了一些代谢参数。
基线瘦素水平为12.2±3.2微克/升。只有体重指数（BMI）与瘦素水平显著相关（p<0.05）。给予rhTSH后，TSH水平显著升高（p<0.001），而甲状腺激素保持不变。最后一次给予rhTSH后20小时，瘦素水平（11.8±3.0微克/升）未发生变化。最大TSH水平与BMI呈负相关（p<0.05），但未发现rhTSH后最大TSH与瘦素水平之间存在相关性。
我们的体内实验模型表明，rhTSH检测后TSH的急性升高对改变循环瘦素水平无效。
