Kalaci Aydner, Duru Mehmet, Karazincir Sinem, Sevinç Teoman Toni, Kuvandik Güven, Balci Ali
Department of Orthopaedics and Traumatology, Faculty of Medicine, Mustafa Kemal University, Antakya, Hatay, Turkey.
Pediatr Emerg Care. 2008 Dec;24(12):842-4. doi: 10.1097/PEC.0b013e31818ea0a5.
We report here an 11-year-old previously healthy girl with isoniazid intoxication who sustained a seizure-induced thoracic compression fracture. The following might be the first such case reported in the medical literature. Isoniazid toxicity should be suspected in any patient who comes to the emergency department with refractory seizures and metabolic acidosis. Forceful muscle contractions during a convulsive seizure can result in vertebral compression fracture, especially in the midthoracic region. A complaint of back pain after isoniazid-induced seizures in patients raises a strong suspicion of vertebral fracture and should be evaluated radiologically.
