Zhernakova Alexandra, van Diemen Cleo C, Wijmenga Cisca
Department of Medical Genetics, University Medical Centre Utrecht, Utrecht 3508 AB, the Netherlands.
Nat Rev Genet. 2009 Jan;10(1):43-55. doi: 10.1038/nrg2489.
Recent genetic studies have revealed shared immunological mechanisms in several immune-related disorders that further our understanding of the development and concomitance of these diseases. Our Review focuses on these shared aspects, using the novel findings of recently performed genome-wide association studies and non-synonymous SNP scans as a starting point. We discuss how identifying new genes that are associated with more than one autoimmune or chronic inflammatory disorder could explain the genetic basis of the shared pathogenesis of immune-related diseases. This analysis helps to highlight the key molecular pathways that are involved in these disorders and the potential roles of novel genes in immune-related diseases.
近期的遗传学研究揭示了几种免疫相关疾病中共同的免疫机制，这加深了我们对这些疾病发生发展及共存关系的理解。我们的综述聚焦于这些共同方面，以近期进行的全基因组关联研究和非同义单核苷酸多态性扫描的新发现为起点展开。我们讨论了识别与不止一种自身免疫性或慢性炎症性疾病相关的新基因如何能够解释免疫相关疾病共同发病机制的遗传基础。这一分析有助于突出这些疾病所涉及的关键分子途径以及新基因在免疫相关疾病中的潜在作用。
