全基因组关联研究：洞察免疫介导疾病的新窗口。
Genome-wide association studies: a new window into immune-mediated diseases.
作者信息
Xavier Ramnik J, Rioux John D
机构信息
Center for Computational and Integrative Biology and Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA.
出版信息
Nat Rev Immunol. 2008 Aug;8(8):631-43. doi: 10.1038/nri2361.
Abstract
Given the recent explosion of genetic discoveries, 2007 is becoming known to human geneticists as the year of genome-wide association studies. In fact, more genetic risk factors for common diseases were identified in this one year than had been collectively reported before 2007. In particular, 2007 witnessed the discovery of many genes that influence susceptibility to individual immune-mediated diseases, as well as other genes that are associated with susceptibility to more than one disease. Although much work remains to be done, in this Review we discuss what effect these studies are having on our understanding of disease pathogenesis and their potential impact on future immunology studies.
摘要
鉴于近期基因发现的激增，2007年正被人类遗传学家称为全基因组关联研究之年。事实上，在这一年里发现的常见疾病的遗传风险因素比2007年之前所有报告的总和还要多。特别是在2007年，发现了许多影响个体免疫介导疾病易感性的基因，以及其他与多种疾病易感性相关的基因。尽管仍有许多工作要做，但在本综述中，我们将讨论这些研究对我们理解疾病发病机制有何影响，以及它们对未来免疫学研究的潜在影响。
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