La Porta Caterina
Department of Biomolecular Science and Biotechnology, University of Milan, Milan, Italy.
Stem Cell Rev Rep. 2009 Mar;5(1):61-5. doi: 10.1007/s12015-008-9048-7. Epub 2008 Dec 18.
The model of cancer stem cells in tumor development states that tumors contain a subset of cells that both self renew and give rise to differentiated progeny. Like normal adult tissue stem cells, cancer stem cells are a minority of the whole tumor and are the only cells that are able to maintain tumor growth indefinitely. In the present review is critically discussed the actually existence of a cancer stem cell subpopulation in melanoma. The self-renewal signaling pathways as well as specific markers like as CD133, ABCB5 and ABCG2 recently identified in putative melanoma cancer stem cells are also discussed.
肿瘤发生中的癌症干细胞模型表明，肿瘤包含一部分既能自我更新又能产生分化后代的细胞。与正常成体组织干细胞一样，癌症干细胞在整个肿瘤中占少数，并且是唯一能够无限期维持肿瘤生长的细胞。在本综述中，对黑色素瘤中癌症干细胞亚群的实际存在进行了批判性讨论。还讨论了最近在假定的黑色素瘤癌症干细胞中发现的自我更新信号通路以及诸如CD133、ABCB5和ABCG2等特定标志物。
