Mostafa Haji-Molla-Hoseini, Ali-Akbar Pourfathollah, Zahra Soheili, Minoo Mohraz, Sedigheh Amini, Mahnaz Aghaiepour, Shahram Samiee, Mahin Nikoogoftar, Mina Moghtadaie
Department of Immunology, School of Medicine, Tarbiat Modarres University, P.O. Box 14115-111, Tehran, Iran.
Pak J Biol Sci. 2007 Jun 15;10(12):2014-9. doi: 10.3923/pjbs.2007.2014.2019.
GB virus type C (GBV-C) probably influences HIV infection associated disease by either directly inhibiting HIV replication or enhancing the immune competence to cope with HIV. Still the definitive mechanisms of this inhibitory effect need to be identified. To address the possibility of immune modulating effects of GBV-C coinfection in HIV patients we evaluated plasma levels of soluble (s) CD26 and CD30 in HIV infected patients with and without GBV-C. Cross-sectional comparison of sCD26 and sCD30 levels among 6 HIV/GBV-C coinfected, 11 HIV mono-infected and 13 healthy controls was carried out. We used a commercial EIA to evaluate sCD26 and scD30 and a RT-PCR assay to detect active GBV-C infection. The Mann-Whitney U test was used for statistical analysis. No statistically significant differences were observed in levels of sCD26 and sCD30 in plasma of HIV infected patients with and without GBV-C viremia. GBV-C infection does not appear to influence the sCD26 and sCD30 levels.
丙型GB病毒（GBV-C）可能通过直接抑制HIV复制或增强应对HIV的免疫能力来影响与HIV感染相关的疾病。不过，这种抑制作用的确切机制仍有待确定。为了探讨GBV-C合并感染对HIV患者免疫调节作用的可能性，我们评估了合并或未合并GBV-C的HIV感染患者血浆中可溶性（s）CD26和CD30的水平。对6例HIV/GBV-C合并感染患者、11例HIV单感染患者和13例健康对照者的sCD26和sCD30水平进行了横断面比较。我们使用商业酶免疫分析（EIA）来评估sCD26和scD30，并使用逆转录聚合酶链反应（RT-PCR）检测法来检测活跃的GBV-C感染。采用曼-惠特尼U检验进行统计分析。在合并或未合并GBV-C病毒血症的HIV感染患者血浆中，未观察到sCD26和sCD30水平存在统计学显著差异。GBV-C感染似乎不会影响sCD26和sCD30水平。
