Dohi T, Anamura S, Shirakawa M, Okamoto H, Tsujimoto A
Department of Pharmacology, Hiroshima University School of Dentistry, Japan.
Jpn J Pharmacol. 1991 Apr;55(4):547-50. doi: 10.1254/jjp.55.547.
Eugenol dose-dependently inhibited 5-HETE (5-hydroxy-5,8,10, 14-eicosatetraenoic acid) and 15-HETE formation by human polymorphonuclear leucocytes. p-Chlorophenol, guaiacol and phenol also inhibited the lipoxygenases. Formation of HETEs by rat dental pulp was inhibited by eugenol and p-chlorophenol. The concentrations of the phenolics required to inhibit lipoxygenases were in the similar range with those used for inhibiting cyclooxygenase. These results showed that phenolic compounds inhibited lipoxygenases and thus suggest that these compounds may be dual inhibitors of lipoxygenase and cyclooxygenase.
丁香酚剂量依赖性地抑制人多形核白细胞生成5-羟二十碳四烯酸（5-HETE）和15-HETE。对氯苯酚、愈创木酚和苯酚也抑制脂氧合酶。丁香酚和对氯苯酚抑制大鼠牙髓生成HETEs。抑制脂氧合酶所需的酚类化合物浓度与抑制环氧化酶所用的浓度范围相似。这些结果表明，酚类化合物抑制脂氧合酶，因此提示这些化合物可能是脂氧合酶和环氧化酶的双重抑制剂。
