Kimura Y, Okuda H, Nomura T, Fukai T, Arichi S
J Nat Prod. 1986 Jul-Aug;49(4):639-44. doi: 10.1021/np50046a013.
The effects of various phenolic compounds isolated from the rootbark of the mulberry tree on rat platelet cyclooxygenase and lipoxygenase products formed from (1-14C)arachiodonic acid were studied. Kuwanons G and H, sanggenon C, and mulberrofuran Q at concentrations of 10(-3) to 10(-4)M inhibited the formation of 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT) and thromboxane B2 (cyclooxygenase products); however, they increased the formation of 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) (a lipoxygenase product). Sanggenon D and mulberrofuran J at concentration of 10(-3)M inhibited the formation of HHT, thromboxane B2, and 12-HETE. Mulberrofuran G at a concentration of 10(-3)M inhibited the formation of HHT, thromboxane B2, and 12-HETE, while at 10(-5)M, it inhibited the formation of 12-HETE without affecting the formations of HHT and thromboxane B2. Kuwanon M and mulberroside A did not affect arachidonate metabolism in rat platelets.
研究了从桑树根皮中分离出的各种酚类化合物对大鼠血小板环氧化酶以及由（1-14C）花生四烯酸生成的脂氧化酶产物的影响。浓度为10（-3）至10（-4）M的桑根酮G和H、桑色素C以及桑呋喃Q抑制了12-羟基-5,8,10-十七碳三烯酸（HHT）和血栓素B2（环氧化酶产物）的生成；然而，它们增加了12-羟基-5,8,10,14-二十碳四烯酸（12-HETE）（一种脂氧化酶产物）的生成。浓度为10（-3）M的桑色素D和桑呋喃J抑制了HHT、血栓素B2和12-HETE的生成。浓度为10（-3）M的桑呋喃G抑制了HHT、血栓素B2和12-HETE的生成，而在10（-5）M时，它抑制了12-HETE的生成，而不影响HHT和血栓素B2的生成。桑根酮M和桑根苷A对大鼠血小板中的花生四烯酸代谢没有影响。
