Jayaraman A, Pike C J
Neuroscience Graduate Programme and Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089-0191, USA.
J Neuroendocrinol. 2009 Jan;21(1):77-81. doi: 10.1111/j.1365-2826.2008.01801.x.
Recent findings indicate that progesterone can attenuate the beneficial neural effects of oestrogen. In the present study, we investigated the hypothesis that progesterone can modulate oestrogen actions by regulating the expression and activity of oestrogen receptors, ERalpha and ERbeta. Our studies in cultured neurones demonstrate that progesterone decreases the expression of both ERalpha and ERbeta and, as a consequence, also reduces both ER-dependent transcriptional activity and neuroprotection. These results identify a potential mechanism by which progesterone antagonises neural oestrogen actions, a finding that may have important implications for hormone therapy in postmenopausal women.
最近的研究结果表明，孕酮可减弱雌激素对神经的有益作用。在本研究中，我们探讨了孕酮可通过调节雌激素受体ERα和ERβ的表达及活性来调节雌激素作用这一假说。我们在培养神经元中的研究表明，孕酮可降低ERα和ERβ的表达，因此也会降低雌激素依赖性转录活性和神经保护作用。这些结果确定了孕酮拮抗神经雌激素作用的一种潜在机制，这一发现可能对绝经后女性的激素治疗具有重要意义。
