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人工耳蜗植入部位头皮的局限性糜烂性脓疱性皮肤病:外用他克莫司治疗成功

Localized erosive pustular dermatosis of the scalp at the site of a cochlear implant: successful treatment with topical tacrolimus.

作者信息

Marzano A V, Ghislanzoni M, Zaghis A, Spinelli D, Crosti C

机构信息

Institute of Dermatological Sciences, University of Milan, IRCCS Polyclinic Foundation, Hospital Mangiagalli and Regina Elena, Milan, Italy.

出版信息

Clin Exp Dermatol. 2009 Jul;34(5):e157-9. doi: 10.1111/j.1365-2230.2008.03054.x. Epub 2008 Dec 15.

Abstract

Erosive pustular dermatosis of the scalp (EPDS) is a rare form of nonmicrobial pustulosis mainly occurring in elderly patients with long-term sun damage to the skin. Clinically, it is characterized by pustular lesions that progressively merge into erosive and crusted areas over the scalp. The histology of EPDS is nonspecific, and its pathophysiology remains undetermined, with various types of local trauma possibly acting as the triggering factor. We describe a 24-year-old woman who developed EPDS after cochlear implant surgery for profound sensorineural hearing loss. We speculate that either the cutaneous surgery during cochlear implantation or the skin inflammation that commonly occurs near the magnet might have triggered the disorder. It is of note that the patient's skin lesions healed completely after treatment with topical tacrolimus, a relatively novel immunosuppressive molecule. Thus, topical tacrolimus may be indicated as a therapeutic alternative to the widely used steroids for this disease, mainly to avoid steroid-related cutaneous atrophy.

摘要

头皮糜烂性脓疱病(EPDS)是一种罕见的非微生物脓疱病,主要发生在皮肤长期受阳光损伤的老年患者中。临床上,其特征为脓疱性病变,这些病变在头皮上逐渐融合成糜烂和结痂区域。EPDS的组织学表现不具有特异性,其病理生理学仍未明确,各种类型的局部创伤可能是触发因素。我们描述了一名24岁女性,她在因极重度感音神经性听力损失接受人工耳蜗植入手术后患上了EPDS。我们推测,人工耳蜗植入过程中的皮肤手术或磁体附近常见的皮肤炎症可能引发了该疾病。值得注意的是,患者在使用局部他克莫司(一种相对新颖的免疫抑制分子)治疗后,皮肤病变完全愈合。因此,局部他克莫司可能作为治疗该疾病的一种替代疗法,以替代广泛使用的类固醇,主要是为了避免类固醇相关的皮肤萎缩。

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