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头皮和四肢慢性萎缩性糜烂性皮肤病:糜烂性脓疱性皮肤病的重新定义。

Chronic atrophic erosive dermatosis of the scalp and extremities: A recharacterization of erosive pustular dermatosis.

作者信息

Patton Douglas, Lynch Peter J, Fung Maxwell A, Fazel Nasim

机构信息

Department of Dermatology, University of California, Davis, 3301 C St, Suite 1400, Sacramento, CA 95816, USA.

出版信息

J Am Acad Dermatol. 2007 Sep;57(3):421-7. doi: 10.1016/j.jaad.2007.04.026. Epub 2007 May 25.

Abstract

BACKGROUND

Erosive pustular dermatosis (EPD) is a rarely reported condition that primarily involves the actinically damaged scalp of elderly women. Although the condition is well recognized in the United Kingdom and Europe, no US cases have heretofore been reported.

OBJECTIVES

We sought to document the presence, and determine the clinical characteristics, of EPD in the US population.

METHODS

Patients were recruited from the dermatology clinic at a university in California and from the private practices of dermatologists in the Northern California region.

RESULTS

Eleven patients with EPD were identified. Eight were women and 3 were men. The scalp was involved in 9 patients and the extremities in two patients. The involved skin was actinically damaged in 9 patients. The patients were elderly (66-90 years) but one patient was a 15-year-old boy. All lesions resolved or greatly improved with the application of high-potency steroids or tacrolimus.

LIMITATIONS

Not all patients were examined personally by the authors of this article. The length of follow-up was relatively short.

CONCLUSIONS

EPD is a fairly common disease and is the most likely diagnosis in instances where chronic, nonhealing, shallow erosions occur on actinically damaged, or otherwise atrophic, skin. In spite of the name, intact pustules are rarely present. The histology is that of moderate to marked, nonspecific chronic inflammation. EPD responds well to high-potency topical steroids.

摘要

背景

糜烂性脓疱性皮肤病(EPD)是一种报道较少的疾病,主要累及老年女性受光化损伤的头皮。尽管该病在英国和欧洲已得到充分认识,但此前美国尚无病例报道。

目的

我们试图记录美国人群中EPD的存在情况,并确定其临床特征。

方法

从加利福尼亚一所大学的皮肤科诊所和北加利福尼亚地区皮肤科医生的私人诊所招募患者。

结果

共确定11例EPD患者。其中8例为女性,3例为男性。9例患者头皮受累,2例患者四肢受累。9例患者受累皮肤存在光化损伤。患者年龄较大(66 - 90岁),但有1例患者为15岁男孩。所有皮损在应用强效类固醇或他克莫司后均消退或明显改善。

局限性

并非所有患者均由本文作者亲自检查。随访时间相对较短。

结论

EPD是一种相当常见的疾病,在受光化损伤或其他萎缩性皮肤上出现慢性、不愈合的浅表糜烂时,最有可能的诊断即为EPD。尽管其名称中有“脓疱”,但完整的脓疱很少出现。组织学表现为中度至重度非特异性慢性炎症。EPD对强效外用类固醇反应良好。

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