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甘露糖结合凝集素通过增强补体激活和多形核细胞摄取，在针对酵母的固有免疫中发挥关键作用。

Mannose binding lectin plays a crucial role in innate immunity against yeast by enhanced complement activation and enhanced uptake of polymorphonuclear cells.

作者信息

van Asbeck Eveline C, Hoepelman Andy I M, Scharringa Jelle, Herpers Bjorn L, Verhoef Jan

机构信息

Eijkman-Winkler Institute for Medical & Clinical Microbiology, Utrecht University Hospital, Utrecht, the Netherlands.

出版信息

BMC Microbiol. 2008 Dec 18;8:229. doi: 10.1186/1471-2180-8-229.

DOI:10.1186/1471-2180-8-229
PMID:19094203
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2627907/
Abstract

BACKGROUND

Mannose binding lectin (MBL) is an important host defence protein against opportunistic fungal pathogens. This carbohydrate-binding protein, an opsonin and lectin pathway activator, binds through multiple lectin domains to the repeating sugar arrays displayed on the surface of a wide range of clinically relevant microbial species. We investigated the contribution of MBL to antifungal innate immunity towards C. parapsilosis in vitro.

RESULTS

High avidity binding was observed between MBL and C. albicans and C. parapsilosis. Addition of MBL to MBL deficient serum increased the deposition of C4 and C3b and enhanced the uptake of C. albicans, C. parapsilosis and acapsular C. neoformans by polymorphonuclear cells (PMNs). Compared to other microorganisms, such as Escherichia coli, Staphylococcus aureus and Cryptococcus neoformans, C. parapsilosis and Candida albicans were potent activators of the lectin pathway.

CONCLUSION

Our results suggest that MBL plays a crucial role in the innate immunity against infections caused by yeast by increasing uptake by PMN.

摘要

背景

甘露糖结合凝集素（MBL）是一种针对机会性真菌病原体的重要宿主防御蛋白。这种碳水化合物结合蛋白作为一种调理素和凝集素途径激活剂，通过多个凝集素结构域与多种临床相关微生物表面展示的重复糖阵列结合。我们在体外研究了MBL对近平滑念珠菌抗真菌固有免疫的贡献。

结果

观察到MBL与白色念珠菌和近平滑念珠菌之间存在高亲和力结合。向MBL缺陷血清中添加MBL可增加C4和C3b的沉积，并增强多形核细胞（PMN）对白色念珠菌、近平滑念珠菌和无荚膜新生隐球菌的摄取。与其他微生物如大肠杆菌、金黄色葡萄球菌和新生隐球菌相比，近平滑念珠菌和白色念珠菌是凝集素途径的有效激活剂。

结论

我们的结果表明，MBL通过增加PMN的摄取，在针对酵母引起的感染的固有免疫中发挥关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe8/2627907/eb6c7567e4aa/1471-2180-8-229-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe8/2627907/5648740a52f8/1471-2180-8-229-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe8/2627907/416babe532ba/1471-2180-8-229-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe8/2627907/b4abbae239f5/1471-2180-8-229-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe8/2627907/eb6c7567e4aa/1471-2180-8-229-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe8/2627907/5648740a52f8/1471-2180-8-229-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe8/2627907/416babe532ba/1471-2180-8-229-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe8/2627907/b4abbae239f5/1471-2180-8-229-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe8/2627907/eb6c7567e4aa/1471-2180-8-229-4.jpg

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