Gan Mei-Fu, Lu Hong-Sheng, Zhang Jian-Wei, Yu Xin-Ru
Department of Pathology, Taizhou Hospital of Zhejiang Province, Linhai 317000, China.
Zhonghua Bing Li Xue Za Zhi. 2008 Oct;37(10):676-9.
To study the pathologic features, diagnosis and differential diagnosis of interdigitating dendritic cell sarcoma (IDCS).
The clinical findings, morphologic features and immunophenotype of 3 cases of IDCS were investigated.
Gross examination showed that IDCS had a greyish-white to greyish-yellow cut surface. The site of occurrence included lung, spleen (with lymph node metastasis) and lymph node. Histologically, the tumor cells were arranged in nests, fascicles and whorls, with intimate admixture of many lymphocytes and plasma cells. They were oval to spindle in shape and contained pale eosinophilic cytoplasm, oval and sometimes grooved nuclei, small distinct nucleoli and ill-defined cell borders. Immunohistochemical study showed that the tumor cells expressed S-100 protein.
IDCS is a rare type of histiocytic and dendritic cell malignancy with distinctive morphologic findings. It needs to be distinguished from follicular dendritic cell sarcoma, inflammatory pseudotumor, Langerhans' cell histiocytosis, malignant melanoma, undifferentiated carcinoma and anaplastic large cell lymphoma. Immunohistochemical staining for S-100 protein is helpful in confirming the diagnosis.
研究指突状树突细胞肉瘤（IDCS）的病理特征、诊断及鉴别诊断。
对3例IDCS的临床资料、形态学特征及免疫表型进行研究。
大体检查显示IDCS切面呈灰白色至灰黄色。发生部位包括肺、脾（伴淋巴结转移）及淋巴结。组织学上，肿瘤细胞呈巢状、束状及漩涡状排列，其间有大量淋巴细胞和浆细胞紧密混合。肿瘤细胞呈椭圆形至梭形，胞质淡嗜酸性，核椭圆形，有时有切迹，核仁小而明显，细胞边界不清。免疫组化研究显示肿瘤细胞表达S-100蛋白。
IDCS是一种罕见的组织细胞和树突状细胞恶性肿瘤，具有独特的形态学表现。需与滤泡树突细胞肉瘤、炎性假瘤、朗格汉斯细胞组织细胞增多症、恶性黑色素瘤、未分化癌及间变性大细胞淋巴瘤相鉴别。S-100蛋白免疫组化染色有助于确诊。
