Wang Hong-Tao, Xu Hong-Yang, Zhang Rong, Liu Zhuo-Gang, Zhang Guo-Jun
1 First Department of Hematology, Shengjing Hospital, China Medical University, Shenyang, Liaoning, P.R. China.
2 Intensive Care Unit, Taizhou Central Hospital, Taizhou, Zhejiang, P.R. China.
J Int Med Res. 2018 Nov;46(11):4791-4799. doi: 10.1177/0300060518792444. Epub 2018 Sep 17.
Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare subtype of dendritic cell neoplasms, and current knowledge on this tumor is limited. We herein report a case of an IDCS in a 64-year-old man who presented with a right inguinal mass combined with extensive retroperitoneal, pulmonary, hepatic, renal, and bone marrow infiltration. Because of the advanced stage of the disease, we performed five cycles of chemotherapy, including cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP); doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD); and ABVD combined with cisplatin, and one cycle of radiotherapy. The patient's inguinal mass became smaller during the treatment, but there was no change in the extent of infiltration at the other sites. The patient died 8 months after the initial diagnosis. We also herein review the etiology, diagnosis, differential diagnosis, treatment, and prognosis of IDCS, and analyze the characteristics of IDCS in Chinese patients.
交错突细胞肉瘤（IDCS）是树突状细胞瘤中一种极其罕见的亚型，目前对该肿瘤的了解有限。我们在此报告一例64岁男性的IDCS病例，该患者表现为右侧腹股沟肿块，并伴有广泛的腹膜后、肺、肝、肾和骨髓浸润。由于疾病分期较晚，我们进行了五个周期的化疗，包括环磷酰胺、阿霉素、长春新碱和泼尼松（CHOP）；阿霉素、博来霉素、长春花碱和达卡巴嗪（ABVD）；以及ABVD联合顺铂，还进行了一个周期的放疗。治疗期间患者的腹股沟肿块变小，但其他部位的浸润范围没有变化。患者在初次诊断后8个月死亡。我们在此还对IDCS的病因、诊断、鉴别诊断、治疗和预后进行了综述，并分析了中国患者中IDCS的特征。
